The MD-380 & MD-UV380 use a 2 pin programming cable. Although its appearance is that of a K1 Kenwood style programming cable where the UART chip is in the USB connector, it is Not compatible. Where many K1 cables have the USB UART chip in the USB connector, the TYT has the chip inside the radio.  The cable itself is straight through and no special drivers are required.  Using a K1 cable from a Kenwood, Wouxun, Baofeng, etc will fail.   Many of the TYT radios ship with the programming cable. Check the product listing before purchasing.